Performance is defined as the achieved work quantity and quality of an employee in performing job. Reliable and professional employee is realized to highly contribute improvement on performance. This corelational study (N=187) was undertaken to analyze the effects of work engagement and job satisfaction on performance of nurses in Syekh Yusuf Regional Hospital of Gowa Regency. The findings revealed that work engagement, represented by the dimensions of vigor, dedication, and absorption, contributed to the performance of nurses. Vigor demonstrated a full mediation to the relationship between work engagement and performance of nurses. Job satisfaction also contributed to elevate the performance of nurses. The study suggests to increase the morale of nurses, support to establish good superior-subordinate relationships, conduct training for helping increase creativity and innovative behavior.