The overall goal of the review is to discuss about establishing a panel of salivary metabolomics markers which may be useful as a non-invasive prognostic markers of oral precancerous and cancerous conditions. The non-invasive panel of salivary metabolomics may be unique in predicting the prognosis of oral pre-cancer and cancerous states, progression of the disease states as well as the effectiveness of treatment. A future research study may be planned to develop a panel of salivary metabolomics for predicting the prognosis of oral leukoplakia as well as oral cancer. It may also predict association of salivary metabolomics with the treatment effectiveness oral cancer. A non-invasive and cost-effective salivary metabolomic parameters may be developed for predicting the prognosis of oral leukoplakia and oral cancer. Sensitivity, specificity and predictive values of salivary metabolomics panel may be compared as routine histopathology in predicting the transformation of precancerous to cancer may be established.