Periodontal diseases are associated with local and systemic risk factors. Stress is one of the risk factors for periodontal diseases. This review is aimed to assess the relationship between the gingival crevicular fluid and salivary levels of psychological stress biomarkers and periodontal disease. The Electronic literature search was conducted through online search engines Pubmed, Scopus, WOS articles published from 2010 to April 2021. Cross-sectional and case-control studies that investigated the association between stress biomarkers and periodontal disease were included. Review paper, animal studies, Interventional studies were excluded from the search. Results from the observational studies suggest that elevated levels of psychological stress biomarkers were observed in salivary and gingival crevicular fluid levels of subjects with periodontal disease in contrast to the healthy controls. Within the limitations of the study Psychological stress biomarkers are correlated with the severity and complexity of periodontal disease