Diabetes mellitus has been described as the most common endocrine disorder that impairs glucose homeostasis resulting in severe complications. Chronic hyperglycemia in diabetic patients is associated with long term damage, dysfunction and eventually the failure of organs, especially the eyes, kidneys, nerves, heart and blood vessels. Currently, there is a renewed interest in the plant based medicines. One such herbal drug, Aloe Vera used for different clinical purposes claimed for its effect on blood glucose levels. Total of 240 type 2 diabetes mellitus patients were enrolled and allocated to four groups viz. A, B, C and D. Group A and C will be given conventional anti-diabetic agents, however Group B and D in addition to anti-diabetic agent, Aloe Vera will be given as add on therapy. While assessing the results and comparing the overall degree of glycaemia control between group A & B, a significant (p<0.004) difference with mean fasting and mean PP blood glucose (p<0.001) were observed. Similarly comparing the overall degree of glycaemia control between group C & D, a significant (p<0.004) difference with mean fasting and mean PP blood glucose (p<0.000) were observed. A significant difference between mean HbA1c recorded before and after the treatment in the groups were treated with Aloe Vera as add on therapy with conventional antidiabetic drugs. The study concluded that the subjects who were treated with Aloe Vera as an add on therapy with conventional antidiabetic drugs has comparatively produced better clinical outcome in terms of glycaemia control and lower incidence of complications.