Background: Chronic kidney disease (CKD) is an emerging global public health problem. The disease is a component of a new epidemic of chronic conditions that replaced malnutrition and infection as the leading cause of mortality during the 21st century. A growing number of patients with chronic renal failure (CRF) rely on non – professional health care providers, such as family and friends, to manage their long term condition throughout the trajectory of CRF. This informal caregivers and experience stress, depression, lack of confidence and poor quality of life. Yet, the needs of caregivers are often neglected and under prioritized. Objectives: - To assess the role strain and coping among caregivers of patients with chronic renal failure and find out the association of coping among caregivers of patients with sociodemographic variables Method: - Quantitative research approach and descriptive research design was adopted. 100 caregivers were selected by Non – probability purposive sampling technique, who met the inclusion criteria. Self – structured socio-demographic proforma was used to collect sociodemographic data and self-structured rating scale for assessment of role strain and coping among caregivers. Results: The findings show showed that the majority of the study sample 64% having moderate coping, others 20% of study sample having poor coping and 16% of the study sample having good coping. The study also revealed that role strain and coping was statistically tested ( p=0.005) is statistically significant. The present study highlights the role of strain and coping among caregivers of patients with chronic renal failure. Conclusion: - Based on the findings of the study, the majority of the samples having sometimes frustration. Most of the samples were moderate coping. There is an association between gender and relativity with the patients and weekly hemodialysis frequency with coping.