ABSTRACT Background: A seizure is a transient occurrence of signs and or symptoms from abnormal excessive or synchronous neuronal activity in the brain. The commonly used treatment for epilepsy is antiepileptic drugs; there is an increased oxidative stress in epilepsy patients, this study was to look for effectiveness of vitamin E in children with treatment resistant epilepsy in the form of improvement in frequency, duration of seizure, number of hospitalization, and EEG change. Subject and Methods: Randomized control trail conducted in 32 children with treatment resistant epilepsy, with supplementation of vitamin E in upper limit of RDA and placebo in addition to antiepileptic drugs after randomization and allocation for 6 months’ duration with prior recording history related to seizure prior to 6 months of trail. Patient kept on follow up with number of seizures, number hospitalization, duration each seizure occurred, changes in antiepileptic drugs made, an EEG after 6 months of intervention. Result: Reduction in seizure frequency, number of hospitalization and duration of seizures occurred in both group, significant difference was observed in number of Impending status seizure episode (p=0.037), there is no significant positive changes in observed. Conclusion: Supplementation of vitamin E as per the upper limit of RDA is effective in reducing the number of impending status seizure, hence the severity of epilepsy in treatment-resistant epileptic patients of the pediatric age group.