Abstract: Background: Diabetic Ketoacidosis (DKA) is an critical and menacing problem of Type 1 as well as type 2 diabetes mellitus (T2DM). DKA is associated with high amount of risk of mortality and morbidity (hospital stay). The prognostic factors of DKA are important factors affecting the outcome of the patients (as treated or death). S. Albumin is one of the prognostic factor less studied up till now. Objectives: To determine Clinical profile of DKA patients: aetiologies, precipitating factors, biochemical parameters and other complications of T2DM patients and to corelate serum albumin level with mortality, duration of stay among DKA patients. Methodology: This cross sectional study will be conducted among 100 diabetic patients with and without ketoacidosis from May 2019 to May 2021. Biochemical parameters: glycated Haemoglobin, urine ketones and serum albumin will be gathered to determine the prognosis. Controls will be adult diabetic patients without ketoacidosis. Data from Cases and controls will be statistically analysed and then compared accordingly. Expected Results: It is expected that decreased Sr. albumin will be associated with poor prognosis in DKA patients. Sr. Albumin might be an indirect prognostic marker of diabetes control due anabolic effect of Insulin, which affects both ketosis possibility and glucose levels. Conclusion: DKA is considered dangerous and life threatening complication of Diabetes mellitus and in spite of all the guidelines of DKA management, they are inadequately managed. There are very few studies done for determining prognostic markers associated with mortality in DKA. Hence, we want to know the role of Serum Albumin in prognosis of patients with diabetic ketoacidosis.