Background: Acute appendicitis is a commonly encountered surgical emergency it has a lifetime prevalence of 1 in 7. With an incidence of 1.5-1.9 per 1000 in male and female population, and 1.4 times more common in men. The diagnosis is based on a thorough clinical history and examination. It is well supported with efficient laboratory investigations like elevated leucocyte count and ultrasound of the abdomen. Acute appendicitis is a common problem yet a difficult diagnosis at times specially in young and elderly females. Females of reproductive group are more prone for other genitourinary problems that may mimic acute appendicitis. Any delay in performing an appendicectomy to improve its diagnostic accuracy, can increase the risk of complications like appendicular lump, perforation and sepsis, which will in turn increase the morbidity and mortality. Aims and Objectives: To evaluate the role of RIPASA scoring system in diagnosis of Acute appendicitis. Material and Methods: The study designed was a prospective, was conducted in the Department of General Surgery, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences (PGIMS), Rohtak, Haryana, India. 154 patients of either sex, Study duration is from December 2019 to January 2021. Considering 95% confidence interval and 80% power of study for sensitivity to be increased from 53% to 68 % sample size is determined to be 100. For specificity to be increased from 80% to 98% sample size is determined to be 156. So, inclusion of both sensitivities of 68% and specificity of 98% sample size is determined to be 154. Patients of age group >15 years and <70 years who present with right iliac fossa pain and with a suspicion of acute appendicitis. RIPASA score for each patient was calculated and diagnosis of acute appendicitis was made. If RIPASA score is <5, then Appendicitis is unlikely, f score is 5.0 to 7.0 then Acute Appendicitis is less likely or can be stated as lowprobability. If score is 7.5 to 11.5 then, High chances of acute appendicitis.