Coronary artery disease (CAD), the leading cause of mortality globally, is one of the major cardiovascular diseases, which results in the buildup of plaque leading to narrowing of coronary arteries. Genetic, environmental and lifestyle factors have an important role in the development of the disease. Moreover, dyslipidemia is a major focus among the risk factors involved in the pathogenesis of CAD. Early diagnosis and management of the disease can be achieved by analyzing the level of biomarkers like NT-proBNP. The study was conducted among 110 test subjects who were dyslipidemic with CAD and 110 control subjects without any chronic illness. The study revealed that test subjects have an increased concentration of NT-proBNP than the control subjects. Moreover, NT-proBNP can also be used as a biomarker for the early prediction of CAD patients with dyslipidemia.