Background &Method: Aim of this study is toevaluate Role of Multidetector computed Tomograpgy in evaluation of Neck Masses. TA prospective study of 60 patients with clinically suspected neck mass was done at our tertiary care hospital. Patients were referred for CT with clinical history/ USG findings of neck mass/ swelling for further characterisation. CT was done for the patients in NCCT and CECT phases. Patients were evaluated with Multi detector CT (TOSHIBA 128 SLICE system). Result:Out of total 60 patient studied in this study, 32 (53.3%) patient were diagnosed malignant on CT one the basis of various CT characteristics which differentiate lesions between benign and malignant lesion. Out of total 32 patients which were diagnosed malignant, majority i.e. 26 (81.2%) were showing heterogeneous contrast enhancement. None of the malignant lesion were showing non enhancement or peripheral enhancement. 08 (26.6%) patients out of 28 benign lesions were demonstrating heterogenous enhancement. Homogenous enhancement were shown by 2 (7.1%) cases of benign lesion. More than half of the benign lesion were showing homogenous or peripheral enhancement i.e. 16 (58%). Majority of the malignant lesion i.e. 22 (68.8 5) were showing necrosis. Among benign lesion 5 (17. 8 %) cases out of total 28 patients were showing necrosis. Bony involvement in the form of lytic erosion were seen in 5 (15.6%) patients out of total 32 patients. No bony involvement were seen in benign lesion. Vascular involvement was seen in 3 (9.3%) patients of malignant lesions and 1 (3.1%) cases of benign lesion. Loss of fat planes with adjacent structure was mostly seen in malignant lesion (60%) as compared to benign lesion (7.1%). Conclusion:Recently developed MDCT enables for thinner collimation with use of MPR, maximum intensity projection and shaded surface display images which improve the localization of the neck lesions. The faster scan acquisitions, less susceptibility to deleterious artifacts from patient motion, ability to be performed in patients with implanted electrical devices are its advantages. CT is a more practical imaging modality due to its relatively lower cost, making it more accessible to patients of lower socioeconomic strata. Since CT is fast, well tolerated, and readily available; it can be used for initial evaluation, preoperative planning, biopsy targeting, and post-operative follow-up and reserve MRI as a complimentary imaging modality or for those tumors that have higher chance of perineural spread.