Aim: To localize and characterize neck lesions with respect to anatomical delineation, extension to adjacent structures and bony involvement. Materials and Methods: For this prospective study the data was collected from patients attending department of radio-diagnosis at LG Hospital, AMCMET medical college, Maninagar Ahmedabad. Total 150 patients presented with symptoms of palpable neck mass and neck pain were recruited. Patients were evaluated with Multidetector CT (Mx Philips 16 slice) and patients who were diagnosed having neck mass on CT scan study. The pathological lesions were evaluated with respect to the density, size of the lesion, location of the lesion, enhancement pattern, presence of calcification, presence of fat, extension into adjoining structures and presence or absence of venous thrombosis and bony involvement.