Abstract: Dengue is a mosquito borne viral disease caused by dengue virus. The incubation period varies from three to fourteen days after bite of an infected mosquito. The symptoms include high fever, vomiting, headache, muscle and joint pain and a characteristic skin rash. Homoeopathy has been proven effective both as prophylactic and in the treatment of dengue fever. Eupatorium perfoliatum is considered one of most effective homoeopathic medicine in the treatment of dengue fever. The prominent symptom of Dengue Fever when Eupatorium Perfoliatum is indicated and can be of great help is – severe muscle and joint pains with high fever. Homeopathic medicine Eupatorium Perfoliatum is also popularly known as “bone set” as it brings about the quickest relief in severe bone and joint pains in fever. The pain can be present in any bone or it can be generalized in the whole body. The patient may also have general body ache with a feeling as if the whole body is broken. Apart from relieving joint pains.