Abstract: Background: Distraction osteogenesis (DO) has become a well known useful procedure now-a-days in the field of oral and maxillofacial surgery, as we know initially this technique was used in the limbs, that is in the long bones but slowly thanks to its success in that area it potentiated the use of this procedure in the mandible, then gradually into the maxilla and now it has become a widely used procedure in the cranio- maxillofacial deformities. This review aims to provide an insight into the role of distraction osteogenesis in the cranio- maxillofacial deformities. Conclusion: The patients with cranio- maxillofacial deformities has more functional problems, poor aesthetics, muscular imbalance, improper oral hygiene, and sequelae of problems will follow it. So, distraction osteogenesis has become boon for those patients with such deformities. Distraction osteogenesis procedure has clinically showed that it is a versatile technique that it can performed with orthognathic surgery with proper planning and also supports the surgical treatment of tmj ankylosis by relaxing the airway obstruction caused by it. The worthiness of this procedure increases day by day in modern surgery and is definitely a key in oral and maxillofacial surgery.