Online ISSN: 2515-8260

ROLE OF DIFFUSION WEIGHTED IMAGING AND DYNAMIC CONTRAST ENHANCED MRI IN PREDICTING BREAST MALIGNANCY

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Dr. Ayush Gupta, Dr. Isha GuptaDr. Hari Prasad Saharan, Dr. Usha Jaipal, Dr. Kuldeep Mendiratta

Abstract

Breast cancer is the most common malignancy in women in both developed and developing countries1 . The incidence of breast cancer is on rise in every country and it presents a great challenge to the entire Healthcare system, the greatest increase is seen in Asian countries1,2. Where the incidence peaks among women in their forties, in contrast to western countries where it peaks among women in their sixties3,4 . Different epidemiological and environmental risk factor associated with breast malignancy are early menarche, late Menopause, nulliparity, elderly primigravida, diminished lactation, excessive exposure to ionizing radiation, family history of breast cancer, previous personal history of breast cancer and other breast diseases such as fibrocystic diseases5 . An early and accurate diagnosis of breast cancer has a favorable prognosis than that of late detection6 . Mammography is an excellent screening modality for detecting breast cancer at clinically occult stage. However it is non-specific and the nature of lesion may not be fully ascertained in many cases7 . Mammography has low predictive value and limited sensitivity in dense breast tissue7 . MRI on the other end is ideal for breast imaging because it is non-invasive, nonirradiating and 3-dimensional modality with its excellent ability to depict soft tissue contrast, it is also used to assess axillary lymph nodal status8 . Dynamic contrast enhanced MRI and DWI have been found to be more accurate in detection of malignancy within dense breast tissue, differentiation of malignancy versus scarring and also in detection of implants. This study aims to assess and compare the diagnostic efficacy of DCE-MRI and DWI in differentiating malignant and benign breast lesions

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