COVID-19 is a very risky inflammation which may lead to death. In this study, a total of (83) patients with corona virus were enrolled in Al- Numan Hospital during the period from 15th February to 15th November 2020. The results of age distribution showed that the age group (40-59) years was most vulnerable 11(45.8%) to acute infection with COVID-19, followed by the age group (20-39) 9(37.5%) P=0.741. The results of antiCOVID-19 IgM antibody (COVID-19 IgM) incidence in the studied cases according to their residency showed that acute incidence of COVID- 19 in rural areas was higher than in urban areas, P=0.090. Laboratory investigations demonstrated that lymphocyte count increased 43(51.8%) cases, while it decreased in 15(18.1%) of them. However, the hemoglobin concentration and the packed cells volume were low for all patients with COVID-19, 83(100.0%). The CRP value was elevated in 76(91.6) of patients in comparison with the control group, P= 0.005.