: Chitosan and its variations, have been used in a variety of scientific domains. Because of its unique physicochemical, biological, ecological, and physiological characteristics, such as biocompatibility, biodegradability, stability in the natural environment, non-toxicity, high biological activity, affordability, chelating of metal ions, and high sorption properties, chitosan is used in a variety of biomedical and industrial processes. The structure is more intriguing because of the reactivity of the amino and hydroxyl groups, which has a variety of uses in dentistry, biotechnology, biosensing, cosmetics, water treatment, and agriculture. Drug delivery, tissue engineering, wound healing, regenerative medicine, blood anticoagulation, and engineering of bone, tendon, or blood vessels are a few of these uses. The present article includes fresh research-based information about the role of chitosan in maintainance of gingival and periodontal health.