Tumor infiltrating lymphocytes (TILs) are candidate as crucial biomarkers, since certain cancers have high lymphocyte infiltration that obtain significant role in specific cancer types that can be contributed in tumor initiation, pathogenesis, progression and may give aid in disease prognosis and therapy. CD4 T cells found to have an important role in bladder cancer immunopathogenesis but still there is no clear view with an argument about their role. In this study we assess the CD4 Th1,Th9,Th17,Th22 cellsinfiltration in tumor and autologous normal microenvironments of urinary bladder and subsequently their significance in antitumor immunology with their clinicopathological influences of urinary bladder cancer.