Abstract: Renal calculi have become a crucial health issue everywhere on the world due to the adjustments in way of life and nutritive propensities for the present time. As of recently, People medication or folklore treatment is the significant reliance for the lithogenesis other than the endoscopic or shock wave lithotripsy. Numerous therapeutic plants were discovered that have antagonistic effect to urolithiatic properties and have been utilized by Ayurveda, homoeopathic medicine, or unani framework. In this paper, we analysed some generally known and as of lately found plant extract which act against lithiasis are discussed. It is mainly focused on lithiasis induced by ethylene glycol utilizing in-vivo experiments. Various experiment shows synergic effect of hyperoxaluria, hypercalciuria, hypocitraturia, decrease in magnesium level and antioxidant properties, change in pH, and elevation in phosphorus and uric acid level leads to the development of lithiaisis. Concentration and the type of the extracting solvent are important for the effectiveness of the extract as it contains different phytochemicals like saponin, flavonoids, phenolic compounds, alkaloids, etc. Generally plants extract which are anti-microbial and have antioxidant properties are helpful in reducing stone formation and protecting from renal injury.