Abstract: Over 100 years of decay, major populace focus on traditional plants for treating massive disease due to the presence of active component. Biologically active compounds present in the medicinal plants have always been of huge curiosity to scientists for focusing on exploring plant products. Nothapodytes foetida (also known as Mappia foetida or Nothapodytes nimmoniana) is an average size tree belonging to family Icacinaceae. It is distributed in Southern India, North India, Srilanka, Myanmar and Thailand. It is an imperative medicinal plant, the foremost source of a potent alkaloid, namely camptothecin, of a wide spectrum of pharmacological activities like anti-cancer, anti-HIV, anti-malarial, antibacterial, anti-oxidant, anti-inflammatory, anti-fungal and also applied in the treatment of anemia. This review article compresses about the phytochemical constituent, pharmacological activity of bioactive component of N.nimmoniana species of root, stem, leaves and bark of the plants.