Since India is an agriculture-based country, organophosphates (OP) still remain the main agent for crop protection and pest control and therefore harm people who are overexposed accidentally while handling the pesticides. Organophosphate compounds are widely used as pesticides in agricultural parts of the world. Organophosphorus pesticide self-poisoning is an important clinical problem in rural regions of the developing world, and kills an estimated 200 000 people every year. Due to their easy availability and low cost, organophosphates are one of the most common causes of poisoning in the world from agricultural, unintentional, or suicidal exposure. The initial management of acute OP poisoning includes cardio respiratory stabilization, decontamination (removal of clothes for possible source of continued exposure in occupational intoxication), irrigation of skin and eyes as well as gastric lavage and activated charcoal to minimize absorption of the OP compound.