Abstract: Among dental diseases, periodontal diseases dominate in their intensity, prevalence and devastating consequences for the dentition of the person. In this regard, the search for effective methods for the diagnosis, treatment and prevention of inflammatory periodontal diseases remains urgent. Recent studies have allowed to expand and complement the modern view in the regulation of many physiological processes of the body. Periodontal diseases are no exception. It is well known that in the complex treatment of periodontal diseases, dentists use a wide arsenal of medications that affect both the microflora of periodontal pockets and various mechanisms of the pathogenesis of the inflammatory process. However, modern methods and tools do not fully justify their clinical effectiveness. In this regard, an integrated approach to the treatment of gingivitis is gaining increasing recognition in dental practice. Aim:To study the causes of hypertrophic gingivitis in adolescence, find optimal treatment options, introduce new methods in the treatment algorithm. Material and research methods. The study used material (oral fluid, gingival blood) obtained from 50 patients aged 12-18 years with a diagnosis of moderate hypertrophic gingivitis and 20 healthy individuals. Depending on the treatment and preventive measures taken, all patients were divided into 2 groups of 25 people each. In the 1st control group for treatment, traditional antiseptic treatment of the oral cavity was used using a 0.05% solution of chlorhexidinebigluconate and periodontal pockets were injected with a metrogel dent gel under a bandage in the amount of 10 g for 5-7 days. In the 2nd group (n = 25), patients underwent anti-microbial, topically anti-inflammatory and decongestant therapy. Traumeel C 301.5 mg in the form of a paste was injected into the interdental space under a dressing in the amount of 10 g for 5-7 days. The 2nd group was taken as the main one. The clinical condition of periodontal tissues was evaluated using the following indices: hygienic (Green-Wermillion), PI (Russel). The state of immune resistance of the oral cavity was evaluated using cytological methods (determination of the content of cellular elements in the liquid of the periodontal pocket); assessment of the absorption activity of neutrophilic leukocytes by calculating the phagocytic number during the induction of phagocytosis by latex particles, as well as the test of spontaneous reduction of nitro blue tetrazolium (HCT test). Statistical data processing was performed on a PVEM using MS Excel 10.0 tools. Results.When examining patients, hyperemia of the gingival mucosa, swelling, loose consistency, bleeding, a small amount of supra and subgingival tartar, profuse soft plaque, false pockets up to 5 mm with serous exudate, papillae enlarged and deformed, hypertrophy up to 1/2 were determined the length of the crown of the teeth, the average value of the clinical indices was IG - 2.58 ± 0.5 and PI - 5.5 ± 0.4. After completion of the course of therapy, improvement was noted in patients of all groups: tightening of the gingival margin, decreased bleeding, disappearance of false pockets. The positive dynamics of changes in the index indicators of the periodontal condition was noted. The highest results were achieved in the 2nd group, where the value of the PI indicator from 2.58 ± 0.5 points to 0.14 ± 0.1, PI from 5.5 ± 0.4 to 2.56 ± 0.8 (p <0.05). Conclusion. Thus, the effectiveness of the local use of the drug "Traumeel C" is confirmed by the results of clinical and laboratory studies.