Background:Dermatophytosis is a common skin diseasein Egypt. It iscaused by keratinophilic fungi. Tinea become chronic, recurrent and resistant to traditional therapies. Isotretinoin is a good adjuvant to systemic antifungal in chronic dermatophytosis due to its keratolytic effect. Aim: This is a prospective study to assess the effectiveness of combined oral itraconazole/isotretinoin therapyin the treatment of chronic and recalcitrant dermatophytosis. Patients and Methods:A total of 30 patients with chronic and/or recalcitrant dermatophytosis were included. Potassium hydroxide microscopy was performed.All the patients received combined oral itraconazole/isotretinoin therapy;Itraconazole 200 mg twice daily with adjuvant isotretinoin20 mg dailyfor 6 weeks. The patients were followed up to 6 monthsfor signs of recurrence. Results:Mycological cure was observed in83.3% andcomplete cureoccurred in 70% of the patients. Conclusions: Combined oral itraconazole/isotretinoin therapycould be an effective treatment in recalcitrant dermatophytosis.