ABSTRACT: The non-surgical periodontal treatment is focused on scaling and root planing, and in an attempt to get better results, the Full-Mouth Disinfection protocol (FMD) is introduced with the aim to perform scaling and root planning within 24 hours, with chlorhexidine solutions and gels(1). The aim of this investigation is to review the literature that exists about FMD, specifically the technique variations, clinic and microbiologic results in chronic periodontitis and clinic and microbiologic results in aggressive periodontitis. Different techniques are applied to this protocol, being the use of manual instruments with an adjunct chlorhexidine therapy for two weeks. The results in chronic periodontitis are similar to those found in the quadrant-based scaling and root planing. The clinical results in aggressive periodontitis show an improvement in pocket depth, bleeding and clinical attachment level, in comparison with the traditional treatment method, when used in conjunction with antibiotic therapy. Microbiologic results in chronic periodontitis show a reduction in pathogen levels the first months post-treatment, but there isn’t a long-term significant difference. Microbiological results in aggressive periodontitis show an significant reduction in levels of pathogens.(2)