Abstract: Tetraketones are one of the significant classes of oxygen containing organic compounds in the area of synthetic organic chemistry because of their various biological applications. Till now, many pathways were suggested by the researchers to achieve the targeted compounds but multi-component reactions are efficient and environment benevolent methods for preparation of several type of bioactive tetraketones. In this report affords have been made to collect the recent literature that describes the present status of tetraketones synthesis via multi-component reactions.