Abstract: The endodontic success relies on chemo mechanical preparation, removal of microbial toxins, irrigation and complete obturation of the root canals. The key part of the treatment is hand and rotary instrumentation to eliminate microorganisms from the primary rootcanal by the action of direct mechanical cleaning.The maingoal of instrumentation is to facilitate disinfection,effective irrigation and filling.The intricacy of rootcanal morphology provides curved apical third,apical deltas, narrow isthmi, oval and ribbon shaped canals cannot be mechanically cleaned.Bacteria can flourish in these untouched areas and it turned out to be a challenging objective to endodontic and also a real cause for pulpal and periapical diseases.Complete disinfection of canal is difficult with single irrigating solution use of two or several irrigating solutions obtain the goals of effective and safe irrigation. Irrigation has been performed with plastic syringe it allows good control of needle depth. The purpose of this article is illuminate the methods of effective and safe irrigation on the latest advancements.