In the early postresuscitation period, we studied the relationship of neurosecretory cells of the supraoptic nucleus and paraventricular nucleus with the B and D basophilic cells of the adenohypophysis in the early stages (I-II-III stages) of postresuscitation disease in animals that underwent a 5-minute clinical death by clamping the vascular bundle of the heart using method B G. Korpacheva (1982). Sham-operated animals served as control. Physiological, morphological, morphometric, histochemical studies and morphofunctional activity of neurosecretory cells of the supraoptic and arcuate nuclei of the hypothalamus, as well as Band D-basophilic cells of the adenohypophysis were carried out. We used image analysis using a Leiss microscope with an electronic micro-attachment connected to an Intel computer, and the content of neurosecretory substances was studied using a cytophotometer. In the early postresuscitation period (stages I-II), there is an increase in morphofunctional activity, which is more pronounced in the NSC SOY, ARN and D-basophilic cells of the adenohypophysis, at the III-stage post-resuscitation disease, there is a further increase in the morphofunctional activity of NSC SOS ARN and B-basophilic cells adenohypophysis, with a shift towards depletion.