ABSTRACT . Purpose is to conduct quality control and standardization methods of a combined action suppository containing benzketasone and papaya extract in accordance with modern requirements of good manufacturing practice. Methods of natural and accelerated storage are used to study the factors affecting the stability of suppositories during storage (type of base used, temperature and storage time). It was revealed that under the conditions of a refrigerating chamber at a temperature of + 3-50 ° C, the studied suppositories practically did not change the quality indicators during 24 months of storage. The type of base slightly affected the change in the physicochemical parameters of the Benzpap and Benzpap 10 suppositories.