Aim: To investigate the quality of vision post-short-term open eye orthokeratology (OK) lens wear. Methods: A total of thirty young adults with myopia between 1.00D to 5.00D wore OK contact lenses for 2 hours in open eye condition in their right eye only. The root-mean-square high order aberrations (RMS-HOA) of the corneal front surface were recorded using Scheimpflug camera. Additionally, unaided visual acuity (VA), objective spherical equivalent refraction (SER), and contrast sensitivity (CS) were recorded using logMAR chart, open field autorefractometer, and CSV-1000 (VectorVision) chart respectively. Data were captured at baseline and post 2 hours of OK lens wear. Results: Significant improvement in VA and SER of 0.42 ± 0.03log (Mean ± SEM, p < 0.0001) and 0.71 ± 0.06D (p < 0.0001) was seen post-OK lens wear respectively. The CS displayed a significant improvement for all spatial frequencies post lens wear. Total RMS values of HOA, RMS spherical aberration (SA; Z12), RMS higher order astigmatism (Z3+Z5) and RMS coma (Z7+Z8) increased by 0.12 ± 0.03µm (p = 0.001), 0.15 ± 0.02µm (p < 0.0001), 0.07 ± 0.06µm (p > 0.05) and 0.08 ± 0.02µm (p = 0.004) respectively post lens wear. Conclusion: Visual acuity and contrast sensitivity demonstrated significant improvement post open eye OK lens wear. However, there was a degradation of visual quality due to an increase in RMSHOA, SA, and coma post lens wear.