Abstract The oral squamous cell carcinoma (OSCC) is evaluated as the eighth driving reason for malignant growth all inclusive. OSCC shows high predominance and grimness, with the death pace of 145,000 passing for every year universally. The result of the treatment and anticipation of oral cancerous growth relies for the most part upon early finding. For the high morbidity of the oral cancer, deferred identification is probably going to be an essential explanation and this backing the basic requirement for sensitive biomarkers to improve early recognition of oral malignant growths. Along these lines, early location and counteraction of oral cancerous growth is one of the destinations set by World Health Organization (WHO). Abnormal cellular products from malignant cells can be recognized and estimated in different body fluids, for example, blood, urine and saliva. Saliva can be utilized to identify biomarkers explicit for oral cancer as it is anything but difficult to acquire and non-intrusive, additionally due to its immediate contact with oral cancer, salivary assessment for discovery of oral cancer can show the best benefit. Biomarkers are utilized for patient assessment in various clinical settings. They are likewise utilized for assessing disease risk, screening for mysterious primary cancers, differentiating benign from malignant findings/one sort of malignancy from another, determining prognosis, acting as indicators/screening, and observing disease status. Salivary biomarkers can possibly recognize normal biological, pathological as well as pharmacological response to treatment. Huge endeavours from scientists and clinicians are significant so as to transform salivary diagnostics into clinical and commercial reality and in this way helping in battling oral disease. This article gives survey of salivary proteomic biomarkers, strategies for examination of salivary proteomic biomarkers and their clinical significance in early discovery of oral cancers.