Abstract: The purpose of this work was to investigate the celery extract's safety impact on liver rats' tissues feeding concentrated diet. A total of 40 rats, randomly divided into 4 groups, each group consists of 10 rats, G1 given normal diet, G2 given concentrated feed diet only for 30 days, G3 given Celery extract 20% of the diet only for 30 days, G4 given concentrated feed diet plus celery extract 20 % of the diet for 30 days. Data from G1, G3 shows that analysis of regular (negative control -ve) livers of rats fed with basal diet or celery 20 per cent provide a normal histologic representation of the liver lobules and normal hepatocytes, whereas the rat's liver fed with a concentrated diet displaying a hepatocyte vacuolar degeneration and hepatocyte fatty degeneration. Furthermore, the testing of rat livers fed with celery-added diet at 20% shows only moderate fatty hepatocyte degeneration. In conclusion, receiving of celery at 20% can lowered the cases of fatty liver and can protect the liver from hydropic degeneration.