Aim: The present paper aims to highlights the prosthodontic management of patients with some common systemic disorders. Background: The increase in life expectancy, more desire for improved standard of life and increased importance to esthetics has resulted in many ambulatory patients with systemic health disorders walking into the dental clinics. Results: Systemic diseases can have a local manifestation with no apparent systemic symptoms or may present with both local as well as systemic reactions. Accordingly, the assessment of medical risks and its relationship to oral health becomes a major area of concern. Conclusion: Dental specialists have a responsibility to contribute to overall health by subsequent maintenance of the oral health. Clinical significance: As certain systemic disorders may produce a pernicious effect on the oral health, it is incumbent for the dental specialists to be aware of the several systemic conditions and also to consider them in the treatment plan.