Postoperative nausea and vomiting (PONV) is one of the most common problems after general anaesthesia causing post operative surgical complications, delayed discharge, psychological and physiological distress for the patients1 . There are many predictive Risk factors that contribute to PONV like Female gender, history of motion sickness, history of PONV2 ,Age, Menstruation, non smoker, general anaesthesia, opioids, Duration of surgery, Laparoscopic and gynaecological surgeries. These patients are routinely screened to reduce the morbidity associated with PONV.2,3 The Mechanism of PONV is complex as there are 3 major pathophysiological pathways involved in PONV, CTZ, vestibulocochlear pathway and gastrointestinal pathway. The specific neurotransmitters serotonin and dopamine have been identified to trigger the emesis in CTZ. Many medications and Multimodal antiemetic therapy have been implemented in the treatment of PONV.3 Serotonin receptor antagonist, ondansetron has been shown to be effective at treating and preventing PONV4 .It inhibits the serotonin receptors in the gastrointestinal tract and causes selective antagonism of the serotonin receptor sites and the vagal afferent nerves and blocks the 5HT3 binding sites at the gastrointestinal tract. and CTZ 5,6 . Current pharmacological antiemetic agents are not without potential adverse effects. Recent studies have suggested the use of aromatic inhalation of 70 % isopropyl alcohol which is known to interfere or influence neurotransmitters at CTZ6 . Therefore, the purpose of this study is to evaluate the effectiveness of inhaled 70% isopropyl alcohol with ondansetron versus ondansetron alone in controlling PONV in patients undergoing laparoscopic surgeries under general anaesthesia. AIM OF THE STUDY • To determine the effectiveness of combining prophylactic inhalation of isopropyl alcohol with iv ondansetron versus ondansetron alone in prevention of PONV.