Abstract: Objective- To evaluate the effect of “progressive muscle relaxation therapy” on the level of anxiety among hospitalized cancer patients. Methods- An quantitative true experimental study was conducted among the cancer patient admitted in the hospital. Non-probability purposive sampling was used to select 50 samples in two groups as a control and treatment group with 25 samples in each group. Pre-test of anxiety was assessed in each group by using a standardized Generalised Anxiety Disorder Questionnaire. The treatment group received progressive muscle relaxation therapy for 15 days where the control group was given the conservative treatment. Again post-test of anxiety was done from each group by using the same tool. The result- It was observed that there was an extremely statistical significance in the level of anxiety in the treatment group and no statistical significance in the level of anxiety in the control group. It also revealed that the level of anxiety showed a significant association with education and occupation. Conclusion- This study concluded that progressive muscle relaxation therapy can be used as an alternative tool to reduce the anxiety level among cancer patients.