Abstract: Reserpine induced orofacial dyskinesia is a well know experimental animal model of Parkinsonism. Generation of free radicals in presence of Reserpine is responsible foroxidative stress induced neurological damage. Reserpine impairs memory and also affects locomotor activity. Anti-oxidant compounds may help in reversal of such neuroleptic induced impairment of cognition and locomotion. In this study, proanthocynidin rich fraction of M. nagi(PMN) possessing antioxidant activity was evaluated for protective effect against reserpine induced cognitive and locomotor impairment. PMN significantly increased number of squares traversed and number of self and supported rearing and transfer latency as compared to reserpine treated group. Reserpine also increased supported rearing compared to self-rearing.