Periodontal disease such as periodontitis is a chronic inflammatory condition of the periodontium that involves interaction between bacterial products, inflammatory mediators and cell population. The inflammatory and immune response due to the long-term presence of subgingival biofilm are protective by intent but results in tissue damage. Substances such as antigen, lipopolysaccharides and other virulence factors are released from the subgingival biofilm which enters into the gingival tissue and an inflammatory response is initiated and leads to the activation of host defense cells. The main reason of the tissue damage is mostly because of the host response which leads to clinical signs and symptoms of periodontal disease, due towhichit is at times referred to as bystander damage.Inflammatory mediators released as a result of cellular activation leads to tissue destruction and bone resorption.