Background : Vigorous growth of cells leads to cancer. Tecoma Stans, a flower which consists of anti - cancer properties. One of such anti - cancer properties is the pro - apoptotic role in melanoma cell line (A375). This is an in vitro study. The intervention is a hydroethanolic extract of Tecomastans on the melanoma cell line. The gene expressions chosen for this study are P53, caspase 3 and caspase 9. Aim of this study is to assess the pro apoptotic role of Tecomastans in melanoma.