Background: Studying medicine is stressful. Stressors of medical students have been described in many studies. “Stress is a body’s non-specific response to demands made upon it, or to disturbing events in the environment”. It is a course by which we feel and cope with environmental threats and challenges. Events which cause stress are referred to as stressors. Stress is nothing but the emotional disturbances or changes caused by stressors. Stress is of two types Favourable Stress – facilitates learning and Unfavourable stresses-suppress learning. Medical students may perceive the same stressors differently based on their inbuilt talents. Excessive amount of stress affect students’ self-esteem, achievement and development in their field. Aim & Objective: Prevalence of stress and its association with Resilience, and coping strategies adopted among Medical Students. Method: Study design: A cross-sectional study. Study setting: Department of Community medicine at tertiary care centre .Study duration: Aug to Nov 2022 Study population: The study population included all MBBS students and interns studding in a tertiary care center. Sample size: Using purposive sampling, a total of 425 medical students from 1st year to internship were included by Using the Cochran formula. Results: Majority of study participants belongs to the age group 18- 22 years e.g 139 (32.70%) followed by 23-27 years age group 127 (29.88%) 98 in 28-32 and 61 students in >33 years age group. majority of study Participants were Females contributing 247 (58.11%) and males 178 (41.89%). Maximum of study participants belongs to the Hindu religion 237 (55.76%) followed by Muslim 81 (19.05%) Buddhist 47 (11.05%) Christian 31 (7.29%) and 29 study participants in other religion. maximum of study participants Duration of Sleep less than 8 hours 297 (69.88%) and 122 participants reported duration of sleep more than 8 hours. maximum of study participants reported that the worried about future 217 (51.05%) followed by academic related 197 (46.35%) 59 participants reported family problems and 33 participants reported other cases of stress. Prevalence of stress among medical students was 57.64%. majority of 1st year students reported stress 97 (39.59%) followed by final year students 53 (21.63%) 2nd year 42 (17.14%), Third year 29 (11.83%) and 24 interns reported stress. Association of coping habits with stress among medical students was statistically Significant at p<0.5. Conclusions: Academic factors are greater perceived cause of stress in medical students in this study. Interventions must be developed to target the particular stressors to reduce the burden on students. The students should be taught various stress management techniques to improve their ability to cope with the demanding professional course. Various programs should be implemented to reduce the stress burden right from the 1st year itself. Teaching stress management and self-care skills to medical students become essential.