Stress is the most common psychological turmoil facing school adolescent function in everyday life. In school life, every school adolescent in one way or another is a victim of stress disorders and many researchers are interested in studying these problems. Hence, a study on “stress among urban and rural high school students and related factors” was conducted during 2022 in MS Ramaiah medical college and Hospital, Bengaluru. The study comprised of 480 Kannada medium students of government and private aided high school from urban and rural areas of field practice area of college. From 8th, 9th and 10th class, 20 students each were taken randomly for the study. General information schedule was used to know the gender, ordinal position, class and type of school of student and structured questionnaire on stressors (Targar, 2009) was used to assess stress among students. The findings from the study revealed that, rural high school students had high level of stress than urban students. Girls were prone to high level of stress than boys and higher the class indicated higher the stress level i.e., 10th class students were more prone to stress. In urban locality, private aided school students were under high level of stress than government school students. This indicates the immediate need for counseling programmers for high school students to reduce the stress during study period as well as during exams.