Objectives: The purpose of this study is to investigate the prevalence and relationships between stress, anxiety, and depression and daytime sleepiness among medical students in the Erode area of Tamil Nadu. Methods: Using a stratified random sample technique, a cross-sectional research of 288 Government Erode Medical College medical students was conducted. The survey was self-administered electronically. The daytime sleepiness, sleep quality, and stress, depression, and anxiety were evaluated by the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index (PSQI), and DASS 42, respectively. Results: Overall, 22.6% of students reported excessive daytime sleepiness. Depression, anxiety, and stress all had prevalence rates of 40.6%, 39.9%, and 29.9%, respectively. 78.5% of people reported having undesirable or poor sleep quality (total PSQI score 5). Epworth Sleepiness Scale Grade and DASS Levels are not correlated (P>0.05). The findings show that women are substantially more stressed than women are (P< 0.05). Stress and poor sleep quality were substantially correlated (P <0.05), indicating that stress level is a significant predictor of poor sleep quality. The study's findings show that students have a high level of stress and poor sleep quality, and they are strongly correlated. We advise creating classes that instruct students on good sleeping habits and coping mechanisms for stressful situations. Medical students were reported to have a significant prevalence of night-time sleepiness and excessive daytime sleepiness. Overuse of mobile devices was found to be causally related to both excessive daytimesleepiness and poor sleep quality. When compared to students who get low quality sleep, the former performed better academically. Those who had low quality sleep showed an escalating pattern of excessive daytime drowsiness. There was a high prevalence of sleep problems, anxiety, stress, and depression among pre-clinical medical students. Those medical students who struggled with their academic performances, poor lifestyle factors, and poor Social and COVID management had significantly higher levels of sleeping disorders, anxiety, stress, and depression.