Hypertension (HTN) and type-2 diabetes mellitus (DM) are now consider as major public health issues. These two multifactorial disorders are the gateway to the cardiovascular diseases. The coexistence of DM and HTN worsens clinical outcomes. Most of the hypertensive and diabetic patients are living in India. The current study was undertaken to find out current scenario of DM, HTN and their coexistence among Indian females and its variation by rural versus urban location. The data of the National Family Health Survey -4 (NFHS-4) were used for this study. Minimum age was 20 and maximum was 49 years. On the basis of age subjects were divided into three cohort: cohort-1(age limit 20-29 years, cohort-2 (age limit 30-39 years) and cohort- 3 (age limit 40-49 years). In this study we used random blood glucose level and blood pressure data for calculating prevalence of DM and HTN. The people with systole blood pressure (SBP) > 140 mmHg and/or diastolic blood pressure (DBP) > 90 mm Hg were considered as hypertensive. People with random blood glucose level > 200 mg / dl were selected as diabetic. Prevalence of HTN varied from 6.68% to 25.43% for rural females and 17.22% to 42.48% for urban females depending on age cohort. Prevalence of HTN increased with advancing age. Maximum percentage of DM (5.23%) was noted in age cohort-3. Coexistence of HTN and DM also observed among Indian adults females. Prevalence of coexistence increased with ageing. Prevalence of DM, HTN and coexistence of both was more among urban than rural female. 20.1% to 47.4% urban female and 8.2% to 26.9% rural Indian females were either hypertensive and or diabetic. High prevalence rates of HTN and its coexistence with DM were observed among adult Indian females. Advancing age and living in urban areas were found to be important risk factors for these public health issues.