Background Nosocomial infections or healthcare-acquired infections are a common cause of increased morbidity and mortality among hospitals patients. Patients are at an increased risk for these infections due to their health states. Considering these adverse effects on and the socioeconomic burden, efforts should be made to minimize the transmission of these infections and make the hospitals a safer environment. These infection rates can be significantly reduced by the implementing and improving compliance with the “care bundles.” the common nosocomial infections such as ventilator-associated pneumonia (VAP), catheter-associated urinary tract infections (CAUTI), and surgical site infections (SSI).ventilator-associated pneumonia (VAP) is the most common nosocomial infection in the intensive care unit (ICU). It is a pulmonary infection that occurs after at least 48 hours of intermittent positive-pressure ventilation (IPPV), and is a leading cause of morbidity and mortality. The incidence of VAP ranges from 10% to 65% of intubated patients depending on the risk factors