Background-Acute coronary syndrome (ACS) remains one of the leading causes of mortality worldwide. The prevalence of Coronary artery disease and the incidence of ACS are very high among Indians. Objectives-The primary aim of this study was to assess the varying clinical presentation of patients with ACS and to determine the effectiveness of various treatment modalities establish an association between base line variable and ACS presentation. Methods-A retrospective descriptive study was conducted in Department of Medicine (Cardiology) in MGM Muthoot Hospital, Kozhencherry for the period of One year. Medical records of patients admitted with ACS during the period of study. A total of 100 patients admitted with ACS through Non probability convenience sampling technique. Results-There is significant association between outcome and Type-II diabetes mellitus.Since the p value is 0.048 is less than 0.05, there is significant association between outcome and Hypertension.Since the p value is 0.528 is greater than 0.05, there is no significant association between outcome and Dyslipidemia but no association with demographic profile. 2 the association between treatment modality and outcome is highly significant (p<0.05). PTCA was found to be most common treatment modalities done in more than 90% of patients. Conclusion-The study reveals that from the Chi-square test analysis, it is found that there is no significant association between outcome and base line variables. But the significant association has been obtained between complications, Treatment modalities and outcome since the ‘p’ value is 0.000.Furthermore, studies with large sample size must be conducted for better accuracy of results with longer duration.