Abstract : Object: The study causal factors, as well as obstetrics outcomes of labor in women with premature rupture of membranes and tactics of labor management. Subject and methods: The study material was the history of childbirth of 106 pregnant women in whom labor was complicated by premature rupture of the membranes in the period from 22-36 weeks of gestation, delivery in the Bukhara regional perinatal center for the period 2017-2019. Results: This article presents the results of a retrospective study in which childbirth was complicated by premature rupture of the membranes. The results show the significant role of premature rupture of the membranes in the development of obstetrics complications, especially in women with aggravated somatic and gynecological anamnesis. Conclusion: Premature discharge of amniotic fluid, as a result of pathological growth of conditionally pathogenic microbiocenosis of cervico-vaginal, which was the cause of chorioamnionitis, which contributed to a significant increase in the specific frequency of obstetrics pathologies.