Abstract. The premorbid period of schizophrenia is caused by various factors and can be considered as one of the most important periods of the patient's life, which affects the further course of schizophrenia and adaptive capabilities, which in turn indicates that the features of the premorbid period also affect the ability of patients with schizophrenia to form therapeutic compliance. The aim of the study was to study the premorbid features of patients with paranoid schizophrenia with cerebral hemodynamic disorders. It should be concluded that ontogenetic biological factors, hereditary burden, cognitive disorders, characterological personal characteristics are risk factors for the development of cerebral vascular dystonia in patients with paranoid schizophrenia.