Premature ejaculation (PE) is very common disease that affect more than 20% of menand the most common self-reported male sexual disorder. The two most relevant and evidence-based definitions of PE are those of International Society for Sexual Medicine (ISSM) and American Psychiatric Association. Both definitions agree on the chronic aspect of this disorder and the relatively short time interval between penetration and ejaculation (≤1min), the absence of voluntary control of ejaculation, and the negative consequences, such as distress in nearly all vaginal penetrations.