Preliminary phytochemical screening is the key step in finding the chemicals that lead to the isolation of lead compounds of medicinal importance. Syzygium malaccense is a large woody climbing shrub that belongs to the Myrtaceae family. Its fruits and leaves are very active from a medical point of view and are used in many traditional medicinal systems. The main objective of this study is to identify and understand the bioactive chemical components of leaf extracts by subjecting the leaf powder to soxhlet extraction in different solvent systems. The phytochemical screening showed the presence of proteins, coumarins, saponins, flavonoids, tannins, and phenolic compounds etc. Total phenolic contents in the methanolic and Aqueous extract of S.malaccenseleaves were found to be 106.21 + 10.85mg/g and 84.09 + 6.32 mg/g equivalent to gallic acid respectively and flavonoid contents in the methanolic and Aqueous extract of S.malaccenseleaves were found to be 80.65 + 7.46 mg/g and 58.54 + 9.21 mg/g equivalent to rutin respectively.Syzygium malaccense leaves methanolic extract has been shown to have high antioxidant activity and powerful ability to scavenge free oxygen radicals, plus the plant's IC50 was nearly equivalent to the standard antioxidant that justified its use in medications. traditional and could represent a good candidate for additional biological and chemical analyzes, and can also be subjected to the isolation of therapeutically active compounds with antioxidant activity and also for additional pharmacological evaluations.