ABSTRACT: Millions of people in the world are suffering from neurological disorders such as Parkinson's, strokes, Alzheimer's, anxiety, Parkinson's and so on. Presently around 1 million people suffer from this disease in the united state. It influences around 1- 2% adults with the age of 65 and 4% adults with the age of 80. Parkinson's disease is one of the most common neurodegenerative disorders that is marked by the damage of dopaminergic neurons and the accumulation of alpha-synuclein. It shows the motor and nonmotor symptoms like tremor, rigidity, and bradykinesia, hyposmia, pain, depression, tiredness, orthostatic hypotension and so on. probiotics are living microorganisms that prevent neurological disorders by altering the gut microbiota in the small intestine. Probiotics used in the treatments of Parkinson's disease which balances the gut microbiomes. Clinical and preclinical data shows the beneficial role of probiotics in the treatment of Parkinson’s disease.