One hundred and fifty blood samples were collected from typhoid patients from selected hospitals in Madurai North . Among the 150 samples, analyzed 74 were recorded positive Salmonella typhi and Salmonella paratyphi. Out of this 74, about 43 were positive for Salmonella typhi and 31 were positive for Salmonella paratyphi. The eight samples were exhibited positive in 1:80 dilution were chosed for further study. Theses 8 samples werer tested against 7 commonly employed antibiotics like Amphicillin, Chloramphenicol, Co-trimoxazole, Ciproflaoxacin, `ceftriaxine, Azithromycin, Ofloxacin and multi drug (Amphicillin +Co – trimoxazole+Chloramphenicol). Antibiogram shows that they are resistant and sensitive to above antibiotics. This study refers that Salmonella typhi isolates were highly sensitive to azithromycin (95%)and it is used as a routine and effective drug for typhoid.