This study aimed to determine the effect of positive deviance approach on reducing the incidence of Dengue Hemorrhagic Fever (DHF) in Pangkep Regency. This studi used mix-method design to identify positive deviance behavior in preventing DHF and intervene by applying the positive deviance to the community in Pangkep Regency. The number of samples for quantitative data was 126 respondents and qualitative data was 12 informants. Data collection was conducted through Focus Group Discussion (FGD) and interviews. The research data were analyzed using logistic regression test and McNemar tests. The results showed the most influential factor in DHF incidence was positive deviance. Positive deviance behavior to prevent DHF were used long-sleeved clothing, use oil, and planting medicinal plants in the yard. The results of the intervention showed there was a significant influence of intervention using a positive deviance approach to increasing the planting of medicinal plants in the yard to prevent DHF, and there was a decrease in the incidence rate of DHF in Pangkep Regency. Positive deviance approach could be used as an effort to prevent and control DHF.