Abstract:Furcation involvement is defined as bone resorption and attachment loss in the bifurcation and trifurcation of multirooted teeth that results from plaque associated periodontal disease. Prevention of periodontal disease progression along with lost periodontal tissues regeneration forms the main goal of periodontal treatment. Plateletrich fibrin (PRF), is a second-generation platelet concentrate incorporates platelets and growth factors within fibrin membranes. In recent times platelet rich fibrin plays a important role periodontal regeneration. The aim of this review is to systematically evaluate the clinical efficacy of platelet rich fibrin as an adjunct in the treatment of grade 2 furcation. A systematic search was carried out in electronic database PubMed and google scholar using the key words furcation, bone defect, plasma rich fibrin. Relevant outcomes and data were extracted from the included studies. Following the removal of the duplicate results, the primary search resulted in 33 articles and 21 articles were excluded based on title and abstract. Hence, 12 articles were read completely for eligibility. After exclusion of 4 irrelevant studies, eight articles were included. All were RCT’s, two human and six animal studies.